POLYNUCLEOTIDE TREATMENT — MARYLEBONE, LONDON
Polynucleotide Treatment in Marylebone
Skin Regeneration With Rejuran, Ameela, Plinest & Vitaran
Your skin already knows how to repair itself — polynucleotide treatment gives it the signal to do exactly that. Four premium brands, one medical team, all at Light Centre, Marylebone.
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Medical Team Led
Pharmaceutical-Grade Products
Face · Under-Eye · Neck · Hands
Rejuran · Ameela · Plinest · Vitaran
★★★★★ 5.0 · 144 Google Reviews
Light Centre, 4 Baker Street, Marylebone
THE SCIENCE, BRIEFLY
Your Skin Already Knows How to Repair Itself.
Polynucleotides, also known as PN or PDRN, are highly purified molecules derived from fish DNA and are biocompatible with the human body. Used safely in medicine for decades, they work by stimulating fibroblast cells to support collagen, elastin, and hyaluronic acid production.
When injected into the skin, polynucleotides help repair, hydrate, and strengthen the skin from within. Unlike fillers, they do not add volume. Instead, they gradually improve skin quality, firmness, texture, and resilience by working with the skin’s natural regenerative processes.
Traditional Skin Boosters (HA)
Included
Adds hyaluronic acid for hydration
Stimulates your own collagen and HA production
Immediate hydration effect
Gradual improvement over weeks
Results last 3–6 months
Results last 6–12 months
FIND YOUR POLYNUCLEOTIDE
Four Premium Brands. One Medically Led Clinic.
Each brand has a distinct formulation, molecular weight, and clinical profile. Our medical team will recommend the most appropriate product for your skin concerns and goals at consultation — but here is what makes each one unique:
Vitaran — The Accessible Starting Point
An excellent introduction to polynucleotide treatment for patients who want to experience the benefits before committing to a premium brand. Supports skin regeneration and improves skin quality, hydration, and texture. Ideal for first-time patients or mild to moderate skin quality concerns.
ORIGIN
European pharmaceutical grade polynucleotides
BEST FOR
First-time patients, mild concerns, prejuvenation
AREAS
Face, under-eye (+£50), neck, hands
Single session: £250
Starter Course (2): £450 — save £50
Plinest — The Italian Innovation
Developed by Mastelli using patented PN-HPT technology, sourced from trout DNA. Available in multiple formulations for different areas and concerns; some combine polynucleotides with hyaluronic acid for immediate hydration alongside longer-term regeneration.
ORIGIN
Mastelli, Italy — patented PN-HPT
BEST FOR
Hybrid hydration + regeneration, under-eye
AREAS
Face, under-eye (+£50), neck, hands
Single session: £320
The Course (3): £800 — save £160
Ameela — The UK Favourite
One of the most widely used and clinically recognised polynucleotide brands in the UK. Particularly well known for improving skin firmness, elasticity and overall quality — and a go-to for under-eye treatment among leading UK practitioners.
ORIGIN
IBSA pharmaceutical, highly purified polynucleotide technology
BEST FOR
Firmness, under-eye hollows, skin quality
AREAS
Face, under-eye (+£50), neck, hands
Single session: £300
The Course (3): £800 — save £100
Rejuran — The Premium Korean Brand
The original Korean polynucleotide skin booster, approved by the Korean MFDS and used by dermatologists since 2014. Known globally as the treatment behind the Korean "glass skin" aesthetic, using highly purified PDRN derived from salmon DNA.
ORIGIN
PharmaResearch Bio, South Korea — MFDS approved since 2014
BEST FOR
Overall skin quality, under-eye, acne scarring
AREAS
Face, under-eye (+£50), neck, hands
Single session: £345
Rejuran (3 + B12): £850 — save £185
Face
From £250 · 30–45 min
Under-Eye
From £300 · 20–30 min
Neck
From £300 · 30–45 min
Hands
From £300 · 20–30 min
WHY A COURSE, NOT ONE SESSION
Collagen Production Compounds. One Session Only Starts It.
A single polynucleotide session begins the repair process. But collagen production is not an event — it is a process. Each session builds on the last, compounding the biological response and delivering results that a single session simply cannot achieve.
AFTER SESSION 1
Once polynucleotides are delivered into the skin, fibroblast activation begins. In the following days, you may notice improved hydration and a subtle glow as the skin’s natural repair process starts.
AFTER SESSION 2 (4 WEEKS LATER)
By session two, collagen production is further stimulated, leading to visible improvements in texture, firmness, pores, fine lines, and overall skin quality.
AFTER SESSION 3 (4 WEEKS LATER)
After a full course, the cumulative results become visible, with skin texture, quality, and resilience at their peak. Results typically last 6 to 12 months.
PACKAGES
Save More. See Better Results. Choose a Course.
A course of polynucleotide treatment delivers significantly better results than a single session — because collagen production compounds with each session. Our packages make the right clinical choice also the most financially sensible one.
The Starter
£450
Save £50
2 x Vitaran sessions
Try polynucleotides before committing to a premium brand.
+ free aftercare guidance
The Course
£800
Save £160
3 sessions — choose Ameela or Plinest
The clinically recommended course for comprehensive results.
Sessions spaced 4 weeks apart.
The Rejuran Premium
£850
Save £185
3 x Rejuran sessions
Our most premium package with the world's most recognised brand.
+ complimentary B12 booster shot
★ Most Popular
WHAT TO EXPECT
Your Polynucleotide Journey at Skin Lab Medispa
01
02
03
04
Consultation & Brand Selection
Treatment
Immediate After
Results & Maintenance
Our medical team reviews your skin and goals, then recommends the right brand, formulation and course. No pressure, no upselling.
A topical anaesthetic is applied before fine-needle injections across the treatment area. Sessions take 20–45 minutes.
Mild redness or small injection marks are normal for 24–48 hours. Return to normal activities the same day.
First improvements visible within 2–4 weeks. Full course results last 6–12 months. Maintenance every 6–9 months.
WHAT OUR PATIENTS SAY
Real Results. Real Patients.
★★★★★
"I had 4mL dermal fillers for masculinisation and definition around my chin and jawline. Dr Ramin was professional, took time to explain what could be achieved, and checked to ensure optimal results. It's rare to find someone who understands male facial features this well!"
— Chris P.
★★★★★
"This was my first time doing any aesthetic procedure. Ramin was so professional in explaining the procedure; he is highly knowledgeable. He did a facial profiling and Botox for me, and the results talk for themselves!"
— Raul
★★★★★
"Honestly couldn't recommend Ramin enough. Went to him for a number of treatments including under eye and cheek filler. The results were excellent and it made a significant impact on the overall aesthetics. He's truly good at what he does."
COMMON QUESTIONS
Polynucleotide Treatment FAQ
THE FULL GUIDE
Everything You Need to Know
What is the difference between Rejuran, Ameela, Plinest and Vitaran?
All four brands use polynucleotides as their active ingredient but differ in source, molecular weight, purity, and formulation. Rejuran: Korean brand using PDRN from salmon DNA, the original and most globally recognised. Ameela: UK favourite using highly purified polynucleotides from IBSA, particularly strong for under-eye. Plinest: Italian brand from Mastelli using patented PN-HPT technology from trout DNA, some versions combine polynucleotides with hyaluronic acid. Vitaran: accessible entry-level option, excellent for first-time patients.
SERVING CENTRAL LONDON
Polynucleotide Treatment Near You — Marylebone & Across Central London
Skin Lab Medispa is located at Light Centre, 4 Baker Street, W1H 6AZ, Marylebone — minutes from Baker Street tube station.
We welcome patients seeking polynucleotide treatment from: Mayfair, Fitzrovia, Kensington, Chelsea, Notting Hill, Paddington, and Westminster — plus searches for Ameela Marylebone, Rejuran London, Plinest London, Vitaran London, salmon DNA skin booster London, polynucleotides under eyes London, and skin regeneration treatment Marylebone.
Same-week appointments available. All four brands stocked. Medical team led.
START YOUR SKIN JOURNEY
Better Skin Starts With One Decision.
Book a consultation at Skin Lab Medispa in Marylebone and our medical team will assess your skin, recommend the right polynucleotide brand and course, and explain exactly what to expect. No pressure. No commitment. Just an honest conversation about what is possible for your skin.
Light Centre, 4 Baker Street, W1H 6AZ · 020 3457 2046