Polynucleotide Treatment in Marylebone -The Complete Patient Guide (2026)
- Ramin
- Jul 7
- 4 min read
Updated: Jul 7
If you have been researching skin quality treatments in London, you have almost certainly come across polynucleotides. Also known as PN, PDRN, or salmon DNA injections, polynucleotide treatment has become one of the most requested aesthetic treatments in the UK and for good reason.
At Skin Lab Medispa in Marylebone, we offer four premium polynucleotide brands: Rejuran, Ameela, Plinest, and Vitaran. This guide explains exactly what polynucleotides are, how they work, what to expect, and how to choose the right brand for your skin.
What Are Polynucleotides?
are naturally occurring biological molecules derived from highly purified fish DNA, usually salmon or trout. They are composed of long chains of nucleotides, the same building blocks that make up human DNA, which is why they are so biocompatible with human skin.
When injected into the skin, polynucleotides interact with your skin's fibroblast cells, the cells responsible for producing collagen, elastin, and hyaluronic acid. They activate a cascade of natural repair and regeneration processes, gradually improving skin quality, texture, hydration, and resilience from within.
The result is not immediate volume or a quick fix. It is a progressive improvement in how your skin actually functions, firmer, smoother, more hydrated, and more resilient. Skin that looks and behaves the way it did years ago.
Why Are Polynucleotides So Popular in 2026?
Polynucleotides have grown dramatically in popularity over the last two years for a simple reason , patients want results that look natural. The era of overfilled faces is over. Patients today want their skin to look healthier, not different. Polynucleotides deliver exactly that genuine improvement in skin quality with zero structural change to the face. Nobody will know you have had a treatment. They will simply notice that your skin looks better.
They have also benefited from strong patient word-of-mouth. Results from a full course are genuinely impressive, and because they develop gradually over weeks, they look completely natural. Patients who complete a course consistently return for maintenance, and they tell their friends.
The Four Brands We Use at Skin Lab Medispa
Not all polynucleotide products are the same. Each brand has a distinct formulation, molecular weight, and clinical profile. Here is what makes each one unique:
Vitaran — From £250Our accessible entry-level polynucleotide option. Excellent for patients new to polynucleotide treatment or those with mild to moderate skin quality concerns who want to experience the benefits before committing to a premium brand.
Ameela — From £300One of the most widely used and clinically recognised polynucleotide brands in the UK. Particularly well known for its effectiveness in improving skin firmness and under-eye treatment. The UK favourite.
Plinest — From £320An Italian brand from Mastelli using patented PN-HPT technology. Available in multiple formulations, with some versions combining polynucleotides with hyaluronic acid for immediate hydration alongside the longer-term regenerative effect.
Rejuran — From £345The original Korean polynucleotide brand, approved by the Korean MFDS since 2014. The most clinically recognised polynucleotide brand in the world and the strongest patient brand recognition in the UK. Our premium option.
Why a Course Beats a Single Session
A single polynucleotide session begins the repair process. But collagen production is not an event,it is a process. Each session builds on the last, compounding the biological response. After session one, you may notice improved hydration and brightness. After session two, skin texture, firmness, and quality improve meaningfully. After session three, the full cumulative effect becomes visible,and results from a complete course typically last 6 to 12 months.
This is why we have designed our packages around courses of 2 and 3 sessions. Patients who complete a course see significantly better, longer-lasting results than those who book a single session.
Who Is Polynucleotide Treatment For?
Polynucleotide treatment is suitable for patients who are noticing a decline in skin quality ,dullness, early fine lines, loss of firmness, crepey texture, or under-eye concerns, and want to address this with a treatment that works with their own biology rather than adding something foreign to their face. It is also excellent as a preventative treatment for younger patients who want to maintain their skin quality before significant signs of ageing appear.
It is not suitable during pregnancy or breastfeeding, for patients with a known fish or seafood allergy, or for those with certain autoimmune conditions. Suitability is always confirmed at consultation.
How Much Does Polynucleotide Treatment Cost in Marylebone?
At Skin Lab Medispa, polynucleotide treatment starts from £250 per session for Vitaran, £300 for Ameela, £320 for Plinest, and £345 for Rejuran.
Course packages are available -The Starter course of 2 Vitaran sessions is £450, The Course of 3 Ameela or Plinest sessions is £800, and The Rejuran Premium course of 3 Rejuran sessions including a complimentary B12 booster shot is £850.
Book Your Polynucleotide Treatment in Marylebone
Skin Lab Medispa is located at Light Centre, 4 Baker Street, London W1H 6AZ- 2 minutes from Baker Street tube station. We offer four premium polynucleotide brands, a medical team, and same-week appointments.
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